Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Abstract The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated
kinase (ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy …

Background Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose
underlying genetic lesion is still obscure. Methods We searched for HCL-associated …

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion
gene landscape in a consecutive series of 195 paediatric B-cell precursor acute …

TCF3-HLF− positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an
integrated approach, we uncovered distinct mutation, gene expression and drug response …

For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is
poor, and there is a need for novel therapies to improve outcome. We screened samples …

We sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute
lymphoblastic leukemias, the largest pediatric cancer genome sequencing effort reported to …

Recent genomic studies have provided a refined genetic map of acute lymphoblastic
leukemia (ALL) and increased the number of potential prognostic markers. Therefore, we …

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the
outcome after relapse is poor. To understand the genetic events that contribute to relapse …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …