This article focuses on the functions of NF-κB that vitally impact lymphocytes and thus
adaptive immunity. NF-κB has long been known to be essential for many of the responses of …

Members of the tumor necrosis factor receptor superfamily (TNFRSF) participate prominently
in B‐cell maturation and function. In particular, B‐cell activating factor belonging to the TNF …

Multiple myeloma, which ranks as the second most common hematological malignancy, is
known for its great genetic heterogeneity. One pathway, however, stands out in this diverse …

The nuclear factor κB or NF-κB transcription factor family plays a key role in several cellular
functions, ie inflammation, apoptosis, cell survival, proliferation, angiogenesis, and innate …

NF‐κB proteins were identified in the search for mechanisms that regulate B‐lymphocyte‐
specific transcription of immunoglobulin κ light chain genes. Twenty‐five years later, though …

B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors
sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during …

The NF-κB pathway, a critical regulator of apoptosis, plays a key role in many normal cellular
functions. Genetic alterations and other mechanisms leading to constitutive activation of the …

Systemic autoimmune disorders are complex heterogeneous chronic diseases involving
many different immune cells. A significant proportion of patients respond poorly to therapy. In …

Bruton's tyrosine kinase (BTK) was discovered due to its importance in B cell development,
and it has a critical role in signal transduction downstream of the B cell receptor (BCR) …

Aberrant B cell signaling plays a critical in role in various systemic and organ-specific
autoimmune diseases. This is supported by genetic evidence by many functional studies in …