The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and
subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in …

Background Multiple neonatal exposures to sevoflurane induce neurocognitive dysfunctions
in rodents. The lack of cell type–specific information after sevoflurane exposure limits the …

Five decades ago, long-term potentiation (LTP) of synaptic transmission was discovered at
entorhinal cortex→ dentate gyrus (EC→ DG) synapses, but the molecular determinants of …

Background Adolescence is a period of increased vulnerability to psychiatric disorders,
including depression. Discovering novel biomarkers to identify individuals who are at high …

Abstract The σ-2 receptor (S2R) complex has been implicated in CNS disorders ranging
from anxiety and depression to neurodegenerative disorders such as Alzheimer's disease …

Axons receive extracellular signals that help to guide growth and synapse formation during
development and to maintain neuronal function and survival during maturity. These signals …

Extracellular vesicles (EVs) are important participants in numerous pathophysiological
processes, and could be used as valuable biomarkers to detect and monitor various …