Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Loss of protein homeostasis (proteostasis) is a common hallmark of aging and age-
associated diseases. Considered as the guardian of proteostasis, the proteostasis network …

Early-life stress experiences can produce lasting impacts on organismal adaptation and
fitness. How transient stress elicits memory-like physiological effects is largely unknown …

Increased activity of the heat shock factor, HSF-1, suppresses proteotoxicity and enhances
longevity. However, the precise mechanisms by which HSF-1 promotes lifespan are unclear …

Neurons are long-lived, terminally differentiated cells with limited regenerative capacity.
Cellular stressors such as endoplasmic reticulum (ER) protein folding stress and membrane …

Life on Earth is astonishingly rich. It comes in many shapes, sizes, and colourations, but also
countless behaviours and molecules. Why is our planet full of life? What are the sources of …

The early environment in which an individual grows up and develops has profound, long-
lasting, and often irreversible consequences for the phenotype throughout the individual …

In recent decades, an influx of aging research has unearthed the possibility that aging is a
governable process. Hundreds of compounds, environmental factors, and genetic …