Protein crystallization was discovered by chance about 150 years ago and was developed
in the late 19th century as a powerful purification tool and as a demonstration of chemical …

The elucidation of the three dimensional structure of biological macromolecules has
provided an important contribution to our current understanding of many basic mechanisms …

Little is known about the evolution of protein structures and the degree of protein structure
conservation over planetary time scales. Here, we report the X-ray crystal structures of seven …

This review explores recent advancements in microfluidic crystallization that use the synergy
of miniaturization technologies and fluid dynamics to enhance precision and control in …

Proteins belong to the most complex colloidal system in terms of their physicochemical
properties, size and conformational-flexibility. This complexity contributes to their great …

Chemoreceptor-based signaling pathways are among the major modes of bacterial signal
transduction, and Pseudomonas aeruginosa PAO1 is an important model to study their …

An emulsion-based serial crystallographic technology has been developed, in which
nanolitre-sized droplets of protein solution are encapsulated in oil and stabilized by …

Protein engineering studies often suggest the emergence of completely new enzyme
functionalities to be highly improbable. However, enzymes likely catalysed many different …

Abstract The NASA mission Perfect Crystals used the microgravity environment on the
International Space Station (ISS) to grow crystals of human manganese superoxide …

Proteins are long chains of amino acid residues that perform a myriad of functions in living
organisms, including enzymatic reactions, signalling, and maintaining structural integrity …