Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …

Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …