The essential functions of molecular chaperones and folding enzymes in maintaining endoplasmic reticulum homeostasis
LM Hendershot, TM Buck, JL Brodsky - Journal of Molecular Biology, 2023 - Elsevier
It has been estimated that up to one-third of the proteins encoded by the human genome
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …
Biological function of HYOU1 in tumors and other diseases
S Rao, L Oyang, J Liang, P Yi, Y Han, X Luo… - OncoTargets and …, 2021 - Taylor & Francis
Various stimuli induce an unfolded protein response to endoplasmic reticulum stress,
accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia …
accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia …
Circular RNA 0025984 ameliorates ischemic stroke injury and protects astrocytes through miR-143-3p/TET1/ORP150 pathway
D Zhou, Z Huang, X Zhu, T Hong, Y Zhao - Molecular neurobiology, 2021 - Springer
Abstract MiR-143-3p is aberrantly expressed in patients with ischemic stroke and associated
with ischemic brain injury. However, the underlying mechanisms are largely unknown. Here …
with ischemic brain injury. However, the underlying mechanisms are largely unknown. Here …
[HTML][HTML] FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response
Z Wang, C Tan, C Duan, J Wu, D Zhou, L Hou, W Qian… - Redox Biology, 2023 - Elsevier
The intestinal epithelial repair after injury is coordinated by intestinal stem cells (ISCs).
Fucosylation catalyzed by fucosyltransferase 2 (FUT2) of the intestinal epithelium is …
Fucosylation catalyzed by fucosyltransferase 2 (FUT2) of the intestinal epithelium is …
Discovery of the First‐in‐Class Inhibitors of Hypoxia Up‐Regulated Protein 1 (HYOU1) Suppressing Pathogenic Fibroblast Activation
D Papadopoulou, V Mavrikaki… - Angewandte Chemie …, 2024 - Wiley Online Library
Fibroblasts are key regulators of inflammation, fibrosis, and cancer. Targeting their activation
in these complex diseases has emerged as a novel strategy to restore tissue homeostasis …
in these complex diseases has emerged as a novel strategy to restore tissue homeostasis …
Recurrent infections and immunodeficiency caused by severe pancytopenia associated with a novel life-threatening mutation in hypoxia-upregulated protein 1
H Jafari Khamirani, M Dianatpour, S Zoghi… - Immunological …, 2022 - Taylor & Francis
ABSTRACT HYOU1 encodes a protein from the endoplasmic reticulum chaperone proteins,
expressed to protect cellular mechanisms from stress such as hypoxia, insufficient energy …
expressed to protect cellular mechanisms from stress such as hypoxia, insufficient energy …