D-amino acids and D-amino acid-containing peptides: potential disease biomarkers and therapeutic targets?

M Abdulbagi, L Wang, O Siddig, B Di, B Li - Biomolecules, 2021 - mdpi.com
In nature, amino acids are found in two forms, L and D enantiomers, except for glycine which
does not have a chiral center. The change of one form to the other will lead to a change in …

Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research

FP Gomes, JR Yates III - Mass spectrometry reviews, 2019 - Wiley Online Library
Progress in proteomics research has led to a demand for powerful analytical tools with high
separation efficiency and sensitivity for confident identification and quantification of proteins …

Analysis of peptide stereochemistry in single cells by capillary electrophoresis–trapped ion mobility spectrometry mass spectrometry

DH Mast, HW Liao, EV Romanova… - Analytical …, 2021 - ACS Publications
Single cell analysis strives to probe molecular heterogeneity in morphologically similar cell
populations through quantitative or qualitative measurements of genetic, proteomic, or …

Spontaneous isomerization of long-lived proteins provides a molecular mechanism for the lysosomal failure observed in Alzheimer's disease

TR Lambeth, DL Riggs, LE Talbert, J Tang… - ACS central …, 2019 - ACS Publications
Proteinaceous aggregation is a well-known observable in Alzheimer's disease (AD), but
failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually …

Does data-independent acquisition data contain hidden gems? A case study related to Alzheimer's disease

EE Hubbard, LR Heil, GE Merrihew… - Journal of proteome …, 2021 - ACS Publications
One of the potential benefits of using data-independent acquisition (DIA) proteomics
protocols is that information not originally targeted by the study may be present and …

Self-propelled micromotors for naked-eye detection of phenylenediamines isomers

R Maria-Hormigos, B Jurado-Sanchez… - Analytical …, 2018 - ACS Publications
Tubular micromotors composed of a hybrid single-wall carbon nanotube (SW)–Fe2O3 outer
layer and powered by a MnO2 catalyst are used for phenylenediamines isomers detection …

Separation of β-Amyloid Tryptic Peptide Species with Isomerized and Racemized l-Aspartic Residues with Ion Mobility in Structures for Lossless Ion Manipulations

G Nagy, K Kedia, IK Attah, SVB Garimella… - Analytical …, 2019 - ACS Publications
Accumulation of β-amyloid (Aβ) is one of the hallmarks of Alzheimer's disease. The
deposition of β-amyloid plaques is likely to start years in advance of manifestation of clinical …

Recent developments in capillary and microchip electroseparations of peptides (2017–mid 2019)

V Kašička - Electrophoresis, 2020 - Wiley Online Library
The review presents a comprehensive survey of recent developments and applications of
high performance capillary and microchip electroseparation methods (zone electrophoresis …

Advancing d-amino acid-containing peptide discovery in the metazoan

DH Mast, JW Checco, JV Sweedler - … et Biophysica Acta (BBA)-Proteins and …, 2021 - Elsevier
The discovery of enzyme-derived d-amino acid-containing peptides (DAACPs) that have
physiological importance in the metazoan challenges previous assumptions about the …

Facile preparation of Cu-doped carbon dots for naked-eye discrimination of phenylenediamine isomers and highly sensitive ratiometric fluorescent detection of H2O2

D Zhao, Y Huang, H Ouyang, B Shi, S Li, S Chen… - Talanta, 2022 - Elsevier
Changing a detection analyte into a colored material is a key challenge for visual
discrimination of isomers. In this work, a novel fluorescent probe incorporating Cu-doped …