Life and death of circulating cell-free DNA

A Kustanovich, R Schwartz, T Peretz… - Cancer biology & …, 2019 - Taylor & Francis
Tumor-specific, circulating cell-free DNA in liquid biopsies is a promising source of
biomarkers for minimally invasive serial monitoring of treatment responses in cancer …

[HTML][HTML] The emerging role of cell-free DNA as a molecular marker for cancer management

AJ Bronkhorst, V Ungerer, S Holdenrieder - Biomolecular detection and …, 2019 - Elsevier
An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …

Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy

C Alix-Panabières, K Pantel - Cancer discovery, 2016 - AACR
Abstract “Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and
circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received …

[HTML][HTML] Origins, structures, and functions of circulating DNA in oncology

AR Thierry, S El Messaoudi, PB Gahan, P Anker… - Cancer and metastasis …, 2016 - Springer
While various clinical applications especially in oncology are now in progress such as
diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural …

Liquid biopsy in breast cancer: A comprehensive review

S Alimirzaie, M Bagherzadeh, MR Akbari - Clinical genetics, 2019 - Wiley Online Library
Breast cancer is the most common cancer among women worldwide. Due to its complexity in
nature, effective breast cancer treatment can encounter many challenges. Traditional …

[HTML][HTML] Techniques of using circulating tumor DNA as a liquid biopsy component in cancer management

M Elazezy, SA Joosse - Computational and structural biotechnology journal, 2018 - Elsevier
Precision medicine in the clinical management of cancer may be achieved through the
diagnostic platform called “liquid biopsy”. This method utilizes the detection of biomarkers in …

DNA in extracellular vesicles: biological and clinical aspects

J Elzanowska, C Semira, B Costa‐Silva - Molecular Oncology, 2021 - Wiley Online Library
The study of extracellular vesicles (EVs), especially in the liquid biopsy field, has rapidly
evolved in recent years. However, most EV studies have focused on RNA or protein content …

Liquid biopsy: monitoring cancer-genetics in the blood

E Crowley, F Di Nicolantonio, F Loupakis… - Nature reviews Clinical …, 2013 - nature.com
Cancer is associated with mutated genes, and analysis of tumour-linked genetic alterations
is increasingly used for diagnostic, prognostic and treatment purposes. The genetic profile of …

[HTML][HTML] The nexus of cfDNA and nuclease biology

DSC Han, YMD Lo - Trends in Genetics, 2021 - cell.com
Cell-free DNA (cfDNA) is a widely used noninvasive biomarker for diagnosis and prognosis
of multiple disease states. Emerging evidence suggests that cfDNA might not just be passive …

Cell-free DNA (cfDNA): clinical significance and utility in cancer shaped by emerging technologies

S Volik, M Alcaide, RD Morin, C Collins - Molecular Cancer Research, 2016 - AACR
Precision oncology is predicated upon the ability to detect specific actionable genomic
alterations and to monitor their adaptive evolution during treatment to counter resistance …