The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways

MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …

The lncRNAs at X chromosome inactivation center: Not just a matter of sex dosage compensation

C Siniscalchi, A Di Palo, A Russo… - International Journal of …, 2022 - mdpi.com
Non-coding RNAs (ncRNAs) constitute the majority of the transcriptome, as the result of
pervasive transcription of the mammalian genome. Different RNA species, such as lncRNAs …

LncRNA ZNF883-mediated NLRP3 inflammasome activation and epilepsy development involve USP47 upregulation

L Gong, Y Han, R Chen, P Yang, C Zhang - Molecular Neurobiology, 2022 - Springer
The goal of this study was to characterize the mechanisms of long noncoding RNA (lncRNA)
ZNF883 regulating NOD-like receptor 3 (NLRP3) inflammasome activation in epilepsy (EP) …

Erinacine a prevents lipopolysaccharide-mediated glial cell activation to protect dopaminergic neurons against inflammatory factor-induced cell death in vitro and in …

SL Lee, JY Hsu, TC Chen, CC Huang, TY Wu… - International Journal of …, 2022 - mdpi.com
Hericium erinaceus (HE) is a common edible mushroom consumed in several Asian
countries and considered to be a medicinal mushroom with neuroprotective effects …

LncRNA PVT1 Promotes neuronal cell apoptosis and neuroinflammation by regulating miR-488-3p/FOXD3/SCN2A axis in epilepsy

F Wen, Z Tan, D Huang, Y Jiang, J Xiang - Neurochemical Research, 2023 - Springer
It is vital to understand the mechanism of epilepsy onset and development. Dysregulated
lncRNAs are closely associated with epilepsy. Our work probed the role of lncRNA …

MicroRNAs in the development of resistance to antiseizure drugs and their potential as biomarkers in pharmacoresistant epilepsy

J Bohosova, J Vajcner, P Jabandziev, H Oslejskova… - …, 2021 - Wiley Online Library
Although many new antiseizure drugs have been developed in the past decade,
approximately 30%–40% of patients remain pharmacoresistant. There are no clinical tools …

Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy

S Chen, M Huang, D Xu, M Li - Neurochemistry International, 2024 - Elsevier
Epilepsy is a common neurological disorder characterized by recurrent seizures with
excessive and abnormal neuronal discharges. Epileptogenesis is usually involved in …

Emerging roles of long non‐coding RNAs in human epilepsy

F Yazarlou, L Lipovich, JA Loeb - Epilepsia, 2024 - Wiley Online Library
Genome‐scale biological studies conducted in the post‐genomic era have revealed that two‐
thirds of human genes do not encode proteins. Most functional non‐coding RNA transcripts …

Long non-coding RNA: an underlying bridge linking neuroinflammation and central nervous system diseases

Z Chen, H Wu, M Zhang - Neurochemistry international, 2021 - Elsevier
Central nervous system (CNS) diseases are responsible for a large proportion of morbidity
and mortality worldwide. CNS diseases caused by intrinsic and extrinsic stimuli stimulate the …

Inhibition of NFAT5‐Dependent Astrocyte Swelling Alleviates Neuropathic Pain

L He, S Ma, Z Ding, Z Huang, Y Zhang, C Xi… - Advanced …, 2024 - Wiley Online Library
Astrocyte swelling is implicated in various neurological disorders. However, whether
astrocyte swelling contributes to neuropathic pain remains elusive. This study elucidates the …