Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …

Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic …

S Ballestri, S Zona, G Targher… - Journal of …, 2016 - Wiley Online Library
Abstract Background and Aim: The magnitude of the risk of incident type 2 diabetes (T2D)
and metabolic syndrome (MetS) among patients with nonalcoholic fatty liver disease …

[HTML][HTML] Non-alcoholic fatty liver disease and diabetes

JM Hazlehurst, C Woods, T Marjot, JF Cobbold… - Metabolism, 2016 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) are common
conditions that regularly co-exist and can act synergistically to drive adverse outcomes. The …

[HTML][HTML] Real-world data reveal a diagnostic gap in non-alcoholic fatty liver disease

M Alexander, AK Loomis, J Fairburn-Beech… - BMC medicine, 2018 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver
disease worldwide. It affects an estimated 20% of the general population, based on cohort …

Novel biomarkers for prediabetes, diabetes, and associated complications

B Dorcely, K Katz, R Jagannathan… - … syndrome and obesity …, 2017 - Taylor & Francis
The number of individuals with prediabetes is expected to grow substantially and estimated
to globally affect 482 million people by 2040. Therefore, effective methods for diagnosing …

Natural antioxidants for non‐alcoholic fatty liver disease: molecular targets and clinical perspectives

F Salomone, J Godos, S Zelber‐Sagi - Liver International, 2016 - Wiley Online Library
Abstract Non‐alcoholic steatohepatitis (NASH), the progressive form of non‐alcoholic fatty
liver disease (NAFLD), is emerging as a main health problem in industrialized countries …

Non alcoholic fatty liver: epidemiology and natural history

M Masarone, A Federico, L Abenavoli… - Reviews on recent …, 2014 - ingentaconnect.com
Non Alcoholic Fatty Liver Disease (NAFLD), defined as the presence of a significant amount
of lipid accumulation in the liver (at least in 5% of hepatocytes), represents a challenging …

Association of nonalcoholic fatty liver disease with lower brain volume in healthy middle-aged adults in the Framingham study

G Weinstein, S Zelber-Sagi, SR Preis, AS Beiser… - JAMA …, 2018 - jamanetwork.com
Importance Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most
often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid …

[HTML][HTML] Hepatic steatosis as a marker of metabolic dysfunction

E Fabbrini, F Magkos - Nutrients, 2015 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of the complex metabolic
derangements associated with obesity. NAFLD is characterized by excessive deposition of …

Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes

P León-Mimila, H Villamil-Ramírez, XS Li, DM Shih… - Diabetes & …, 2021 - Elsevier
Abstract Aims Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been
associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty …