Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Progress in pig organ xenotransplantation has been made largely through (1) genetic
engineering of the organ-source pig to protect its tissues from the human innate immune …

We report orthotopic (life‐supporting) survival of genetically engineered porcine cardiac
xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work …

Xenotransplantation using porcine donors is rapidly approaching clinical applicability as an
alternative therapy for treatment of many end-stage diseases including type 1 diabetes …

This review will detail the current status of islet xenotransplantation as a potential treatment
for type I diabetes mellitus, focusing on recent advances in porcine xenogeneic islet …

We discuss what therapeutic regimen might be acceptable/successful in the first clinical trial
of genetically engineered pig kidney or heart transplantation. As regimens based on a …

Abstract Purpose of Review Porcine islets represent a potentially attractive beta-cell source
for xenotransplantation into patients with type 1 diabetes, who are not eligible to islet allo …

Progress in life-supporting kidney transplantation in the genetically-engineered pig-to-
nonhuman primate model has been encouraging, with pig kidneys sometimes supporting …

Type 1 diabetes is a disease resulting from autoimmune destruction of the insulin-producing
beta cells in the pancreas. When type 1 diabetes develops into severe secondary …

Background Xenotransplantation using pig cells, tissues and organs may help to overcome
the shortage of human tissues and organs for the treatment of tissue and organ failure …