Future of antibody purification

D Low, R O'Leary, NS Pujar - Journal of Chromatography B, 2007 - Elsevier
Antibody purification seems to be safely ensconced in a platform, now well-established by
way of multiple commercialized antibody processes. However, natural evolution compels us …

Plants as bioreactors: recent developments and emerging opportunities

AK Sharma, MK Sharma - Biotechnology advances, 2009 - Elsevier
In recent years, the use of plants as bioreactors has emerged as an exciting area of research
and significant advances have created new opportunities. The driving forces behind the …

ELPylated anti‐human TNF therapeutic single‐domain antibodies for prevention of lethal septic shock

U Conrad, I Plagmann, S Malchow… - Plant biotechnology …, 2011 - Wiley Online Library
Tumour necrosis factor (TNF) is a major pro‐inflammatory cytokine involved in multiple
inflammatory diseases. The detrimental activity of TNF can be blocked by various …

An antibody produced in tobacco expressing a hybrid β-1, 4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes

H Bakker, GJA Rouwendal… - Proceedings of the …, 2006 - National Acad Sciences
N-glycosylation of a mAb may have a major impact on its therapeutic merits. Here, we
demonstrate that expression of a hybrid enzyme (called xylGalT), consisting of the N …

[图书][B] Plant breeding and biotechnology: societal context and the future of agriculture.

D Murphy - 2007 - cabidigitallibrary.org
This comprehensive survey of modern plant breeding traces its history from the earliest
experiments at the dawn of the scientific revolution in the seventeenth century to the present …

Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals

PAC Sparrow, JA Irwin, PJ Dale, RM Twyman… - Transgenic …, 2007 - Springer
Significant advances over the last few years have seen plant-made pharmaceuticals (PMPs)
move from the exploratory research phase towards clinical trials, with the first commercial …

Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants

A Spök, RM Twyman, R Fischer, JKC Ma… - Trends in …, 2008 - cell.com
The use of genetically modified (GM) plants to synthesize proteins that are subsequently
processed, regulated and sold as pharmaceuticals challenges two very different established …

Immunological aspects of using plant cells as delivery vehicles for oral vaccines

S Rosales-Mendoza… - Expert review of …, 2014 - Taylor & Francis
Genetically engineered plants can be used for the biomanufacture and delivery of oral
vaccines. Although a myriad of antigens have been produced using this approach …

Current status of viral expression systems in plants and perspectives for oral vaccines development

JA Salazar-González, B Bañuelos-Hernández… - Plant molecular …, 2015 - Springer
During the last 25 years, the technology to produce recombinant vaccines in plant cells has
evolved from modest proofs of the concept to viable technologies adopted by some …

Genetically modified crops for the bioeconomy: meeting public and regulatory expectations

SM Chapotin, JD Wolt - Transgenic research, 2007 - Springer
Abstract As the United States moves toward a plant-based bioeconomy, a large research
and development effort is focused on creating new feedstocks to meet biomass demand for …