Tolerance and exhaustion: defining mechanisms of T cell dysfunction
A Schietinger, PD Greenberg - Trends in immunology, 2014 - cell.com
CD8 T cell activation and differentiation are tightly controlled, and dependent on the context
in which naïve T cells encounter antigen, can either result in functional memory or T cell …
in which naïve T cells encounter antigen, can either result in functional memory or T cell …
Hallmarks of the aging T‐cell system
The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …
[HTML][HTML] Commensal bacteria calibrate the activation threshold of innate antiviral immunity
Signals from commensal bacteria can influence immune cell development and susceptibility
to infectious or inflammatory diseases. However, the mechanisms by which commensal …
to infectious or inflammatory diseases. However, the mechanisms by which commensal …
Epigenetics and bacterial infections
Epigenetic mechanisms regulate expression of the genome to generate various cell types
during development or orchestrate cellular responses to external stimuli. Recent studies …
during development or orchestrate cellular responses to external stimuli. Recent studies …
[HTML][HTML] Aberrant epigenetic landscape in cancer: how cellular identity goes awry
M Berdasco, M Esteller - Developmental cell, 2010 - cell.com
Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …
Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?
CD8+ T cells have been described as being naive or one of 4 antigen (Ag)-experienced
subtypes representing a continuum of differentiation and maturation: T memory stem cell …
subtypes representing a continuum of differentiation and maturation: T memory stem cell …
The future of human DNA vaccines
L Li, F Saade, N Petrovsky - Journal of biotechnology, 2012 - Elsevier
DNA vaccines have evolved greatly over the last 20 years since their invention, but have yet
to become a competitive alternative to conventional protein or carbohydrate based human …
to become a competitive alternative to conventional protein or carbohydrate based human …
[HTML][HTML] DNA methylation patterns in CD4+ T-cells separate psoriasis patients from healthy controls, and skin psoriasis from psoriatic arthritis
V Natoli, A Charras, SR Hofmann, S Northey… - Frontiers in …, 2023 - frontiersin.org
Background Psoriasis is an autoimmune/inflammatory disorder primarily affecting the skin.
Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately …
Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately …
[HTML][HTML] DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes
Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for
example, discordance rates for autoimmune diseases are 20%–80%. MZ discordance …
example, discordance rates for autoimmune diseases are 20%–80%. MZ discordance …
[HTML][HTML] Attenuation of rheumatoid inflammation by sodium butyrate through reciprocal targeting of HDAC2 in osteoclasts and HDAC8 in T cells
DS Kim, JE Kwon, SH Lee, EK Kim, JG Ryu… - Frontiers in …, 2018 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by both genetic and
environmental factors. Recently, investigators have focused on the gut microbiota, which is …
environmental factors. Recently, investigators have focused on the gut microbiota, which is …