Direct or indirect exposure to inorganic arsenic (iAs) in the forms of AsIII (arsenite) and AsV
(arsenate) through consumption of As-contaminated food materials and drinking water leads …

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

Anemia is very common in patients with inflammatory disorders. Its prevalence is associated
with severity of the underlying disease, and it negatively affects quality of life and cardio …

Almost half of all enzymes must associate with a particular metal to function. An ambition is
to understand why each metal–protein partnership arose and how it is maintained. Metal …

Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided
new insights into the pathogenesis of anaemia associated with renal failure and has led to …