Highlights•Urotensin II is a cyclic undecapeptide involved in cardiovascular
regulation.•Pseudo-irreversible binding to UT receptor could explain urotensin II low …

The urotensinergic system, comprised of a G protein-coupled receptor (UT) and two
endogenous ligands named urotensin II (UII) and urotensin II-related peptide (URP), has …

While the urotensinergic system plays a role in influencing various pathologies, its potential
remains untapped because of the absence of therapeutically effective urotensin II receptor …

In accordance with their common but also divergent physiological actions, human urotensin
II (1) and urotensin II-related peptide (2) could stabilize specific urotensin II receptor (UTR) …

Cyclic azasulfuryl (As) peptide analogs of the urotensin II (UII, 1, H-Glu-Thr-Pro-Asp-c [Cys-
Phe-Trp-Lys-Tyr-Cys]-Val-OH) fragment 4–11 were synthesized to explore the influences of …

Urotensin‐II (UT‐II) and its receptor (UTR) are involved in the occurrence of different
epithelial cancers. In particular, UTR was found overexpressed on colon, bladder, and …

Intimal hyperplasia (IH) is a common pathological feature of vascular proliferative diseases,
such as atherosclerosis and restenosis after angioplasty. Urotensin II (UII) and its receptor …

The receptor for the urokinase-type plasminogen activator (uPAR) is a widely recognized
master regulator of cell migration. We and others have previously documented that the …

The urotensin-II receptor (UTR) is a class A GPCR that predominantly binds to the
pleiotropic cyclic peptide urotensin-II (U-II). U-II is constrained by a disulfide bridge that …

Urotensin II (UII) and urotensin II-related peptide (URP) are functionally selective,
suggesting that these two hormones might play distinct physiological role through different …