Synthesis of new hydrazone derivatives and evaluation of their monoamine oxidase inhibitory activity

F Tok, BN Sağlık, Y Özkay, S Ilgın, ZA Kaplancıklı… - Bioorganic …, 2021 - Elsevier
A novel series of hydrazone derivatives were designed and synthesized. Their structures
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …

Homoleptic metal complexes derived from hydrazones as ligand; synthesis, cytotoxic activity, photoluminescence properties and ADMET studies

AO Sarıoğlu, Z Bulut, DT Kahraman, S Güler… - Journal of Molecular …, 2024 - Elsevier
In the present work, N'-(2‑hydroxy-5-nitrobenzylidene) thiophene-2-carbohydrazide (L) and
its Cu (II), Ni (II), Co (II), and Fe (II) complexes have been prepared. Their chemical …

Spectroscopic, crystal structural, theoretical and biological studies of phenylacetohydrazide Schiff base derivatives and their copper complexes

SM El-Medani, AA Makhlouf, H Moustafa… - Journal of Molecular …, 2020 - Elsevier
Two phenylacetohydrazide Schiff base derivatives: N'-(1-(2-hydroxyphenyl) ethylidene))-2-
phenylacetohydrazide, HL1, and N'-((1-hydroxynaphthalen-2-yl) methylene)-2 …

Design, synthesis, biological activity evaluation and in silico studies of new nicotinohydrazide derivatives as multi-targeted inhibitors for Alzheimer's disease

F Tok, BN Sağlık, Y Özkay, ZA Kaplancıklı… - Journal of Molecular …, 2022 - Elsevier
A new series of 6‑chloro-N'-(substituted benzylidene) nicotinohydrazide were synthesized
via condensation reactions between the corresponding hydrazides and aldehydes. All …

Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard's T and P reagents

N Stevanović, PP Mazzeo, A Bacchi, IZ Matić… - JBIC Journal of …, 2021 - Springer
In this work synthesis, characterization and crystal structures of 1, Zn (II) complex ([Zn L 1
(NCS) 2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene) hydrazinyl) ethyl) pyridin-1-ium …

Spectroscopic, density functional theory, nonlinear optical properties and in vitro biological studies of Co (II), Ni (II), and Cu (II) complexes of hydrazide Schiff base …

RM Ramadan, SM El‐Medani… - Applied …, 2021 - Wiley Online Library
Complexes of three molecularly designed phenylacetohydrazide Schiff base derivatives—
N′‐(2‐hydroxybenzylidene)‐2‐phenylacetohydrazid (HL1), N‐(1‐(2‐hydroxyphenyl) …

N‐Substituted Arylidene‐3‐(Methylsulfonyl)‐2‐Oxoimidazolidine‐1‐Carbohydrazide as Cholinesterase Inhibitors: Design, Synthesis, and Molecular Docking Study

F Tok, BN Sağlık, Y Özkay, ZA Kaplancıklı… - Chemistry & …, 2022 - Wiley Online Library
The development of new enzyme inhibitors in degenerative brain diseases has gained more
attention. Enzyme inhibitors play an effective role in controlling central nervous system …

Design, synthesis, molecular modeling, in vitro evaluation of novel piperidine‐containing hydrazone derivatives as cholinesterase inhibitors

F Tok, N Baltaş, Bİ Abas, G Tatar Yılmaz… - Drug Development …, 2024 - Wiley Online Library
In an effort to develop new and effective therapeutic agents for Alzheimer's disease, a series
of hydrazone derivatives bearing piperidine rings have been designed and synthesized. The …

Optimization of biotransformation process for the synthesis of pyrazine-2-carboxylic acid hydrazide using acyltransferase activity of Bacillus smithii IITR6b2 in batch …

S Lavania, B Choudhury - Biocatalysis and Biotransformation, 2024 - Taylor & Francis
The synthesis of pyrazine-2-carboxylic acid hydrazide, a heterocyclic hydrazide compound,
with negligible production of the by-product (pyrazine-2-carboxylic acid) in a solvent-free …

Synthesis of some novel 1, 3, 4-oxadiazole derivatives and evaluation of their antimicrobial activity

F Tok, M Kaya, H Karaca… - Synthetic …, 2022 - Taylor & Francis
Abstract Treatment for microbial infections still remains an important health problem for
researchers around the world. Despite a broad range of antimicrobial drugs today, there are …