In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …

FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling,
including receptor maturation, hormone binding and nuclear translocation. Although …

Context Estradiol is the primary female sex hormone and plays an important role for skeletal
health in both sexes. Several enzymes are involved in estradiol metabolism, but few …

Hsp90 is an essential molecular chaperone responsible for the folding and activation of
hundreds of 'client'proteins, including the glucocorticoid receptor (GR). Previously, we …

In this article we summarize the birth of the field of nuclear receptors, the discovery of
untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of …

Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …

HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …

Hsp90 binding immunophilins FKBP51 and FKBP52 modulate steroid receptor trafficking
and hormone-dependent biological responses. With the purpose to expand this model to …

The Hsp90 co-chaperones FKBP51 and FKBP52 play key roles in steroid-hormone-receptor
regulation, stress-related disorders, and sexual embryonic development. As a prominent …

Background The salmon louse is an ectoparasitic copepod that causes major economic
losses in the aquaculture industry of Atlantic salmon. This host displays a high level of …