An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity

E Masini, E Loi, AF Vega-Benedetti, M Carta… - International journal of …, 2020 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …

The rationale for vitamin, mineral, and cofactor treatment in the precision medical care of autism spectrum disorder

NLR Indika, RE Frye, DA Rossignol, SC Owens… - Journal of personalized …, 2023 - mdpi.com
Children with autism spectrum disorder may exhibit nutritional deficiencies due to reduced
intake, genetic variants, autoantibodies interfering with vitamin transport, and the …

Propionic acid induces alterations in mitochondrial morphology and dynamics in SH-SY5Y cells

E Buchanan, C Mahony, S Bam, M Jaffer, S Macleod… - Scientific Reports, 2023 - nature.com
Propionic acid (PPA) is used to study the role of mitochondrial dysfunction in
neurodevelopmental conditions like autism spectrum disorders. PPA is known to disrupt …

Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways

W Zhang, M Zhang, Z Xu, H Yan, H Wang… - Nature …, 2023 - nature.com
Identifying genes whose expression is associated with schizophrenia (SCZ) risk by
transcriptome-wide association studies (TWAS) facilitates downstream experimental studies …

The effectiveness of cobalamin (B12) treatment for autism spectrum disorder: a systematic review and meta-analysis

DA Rossignol, RE Frye - Journal of personalized medicine, 2021 - mdpi.com
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder affecting 2% of
children in the United States. Biochemical abnormalities associated with ASD include …

An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes

T Yardeni, AG Cristancho, AJ McCoy… - Proceedings of the …, 2021 - National Acad Sciences
Autism spectrum disorders (ASDs) are characterized by a deficit in social communication,
pathologic repetitive behaviors, restricted interests, and electroencephalogram (EEG) …

The mitochondrial dysfunction hypothesis in autism spectrum disorders: current status and future perspectives

L Citrigno, M Muglia, A Qualtieri, P Spadafora… - International journal of …, 2020 - mdpi.com
Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental
conditions, characterized by a wide genetic variability that has led to hypothesize a …

Melatonin: Regulation of viral phase separation and Epitranscriptomics in post-acute sequelae of COVID-19

D Loh, RJ Reiter - International journal of molecular sciences, 2022 - mdpi.com
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure
on herd immunity and demands versatile adaptations by the human host genome to counter …

Mitochondrial dysfunction in cognitive neurodevelopmental disorders: Cause or effect?

A Anitha, I Thanseem, M Iype, SV Thomas - Mitochondrion, 2023 - Elsevier
Mitochondria have a crucial role in brain development and neurogenesis, both in embryonic
and adult brains. Since the brain is the highest energy consuming organ, it is highly …

Clustered protocadherins emerge as novel susceptibility loci for mental disorders

Z Jia, Q Wu - Frontiers in neuroscience, 2020 - frontiersin.org
The clustered protocadherins (cPcdhs) are a subfamily of type I single-pass transmembrane
cell adhesion molecules predominantly expressed in the brain. Their stochastic and …