Cell death pathways in ischemic stroke and targeted pharmacotherapy
Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …
[HTML][HTML] Excitotoxicity and stroke: identifying novel targets for neuroprotection
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
Role of inflammation and its mediators in acute ischemic stroke
Inflammation plays an important role in the pathogenesis of ischemic stroke and other forms
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …
of ischemic brain injury. Increasing evidence suggests that inflammatory response is a …
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
B Kaminska - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2005 - Elsevier
Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …
Molecular targets in cerebral ischemia for developing novel therapeutics
SL Mehta, N Manhas, R Raghubir - Brain research reviews, 2007 - Elsevier
Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …
Reactive astrocytes and therapeutic potential in focal ischemic stroke
GR Choudhury, S Ding - Neurobiology of disease, 2016 - Elsevier
Astrocytes are specialized and the most abundant cell type in the central nervous system
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
Post‐ischemic brain damage: pathophysiology and role of inflammatory mediators
Neuroinflammatory mediators play a crucial role in the pathophysiology of brain ischemia,
exerting either deleterious effects on the progression of tissue damage or beneficial roles …
exerting either deleterious effects on the progression of tissue damage or beneficial roles …
TNF receptor subtype signalling: differences and cellular consequences
DJ MacEwan - Cellular signalling, 2002 - Elsevier
Tumour necrosis factor-α (TNFα) is a multifunctional cytokine belonging to a family of ligands
with an associated family of receptor proteins. The pleiotropic actions of TNF range from …
with an associated family of receptor proteins. The pleiotropic actions of TNF range from …
The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer
HY Yong, MS Koh, A Moon - Expert opinion on investigational …, 2009 - Taylor & Francis
Background: The p38 mitogen-activated protein kinase (MAPK) is activated by various pro-
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …
[HTML][HTML] TNF ligands and receptors–a matter of life and death
DJ MacEwan - British journal of pharmacology, 2002 - ncbi.nlm.nih.gov
Abbreviations: Apaf, apoptosis protease activation factor; CAD, caspase-activated DNAse;
caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; …
caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; …