Recent developments have revolutionized the study of biomolecules. Among them are
molecular markers, amplification and sequencing of nucleic acids. The latter is classified into …

One of the main problems in chemotherapy using platinum drugs as anticancer agents is the
resistance phenomenon. Synthesizing and evaluating valid alternative compounds is …

Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD);
however, they are poorly characterized. We performed paired single-cell RNA and B-cell …

Little is known of the geospatial architecture of individual cell populations in lung
adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of …

Background Implementation of high-risk human papillomavirus (hrHPV) screening has
greatly reduced the incidence and mortality of cervical cancer. However, a triage strategy …

The epigenome coordinates spatial-temporal specific gene expression during development
and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval …

Supranucleosomal chromatin structure, including chromatin domain conformation, is
involved in the regulation of gene expression and its dysregulation has been associated …

Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD)
development is needed to devise intervention strategies. Here we studied 246,102 single …

Simple Summary Advances in lung cancer screening have led to a growing need for early
intervention strategies for the expanding cohort of patients being diagnosed with the number …

Introduction Local and regional recurrence after surgical intervention is a significant problem
in cancer management. The multistage theory of carcinogenesis precisely places the …