The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …

Understanding transdifferentiation—the conversion of one differentiated cell type into
another—is important from both basic science and clinical perspectives. In Caenorhabditis …

A diversity of gene regulatory mechanisms drives the changes in gene expression required
for animal development. Here, we discuss the developmental roles of a class of gene …

Vasa homologs are ATP-dependent DEAD-box helicases, multipotency factors, and critical
components that specify and protect the germline. They regulate translation, amplify piRNAs …

Caenorhabditis elegans early embryos generate cell-specific transcriptomes despite lacking
active transcription, thereby presenting an opportunity to study mechanisms of post …

While Caenorhabditis elegans was originally regarded as a model for investigating
determinate developmental programs, landmark studies have subsequently shown that the …

RNA interference is a crucial gene regulatory mechanism in Caenorhabditis elegans. Phase-
separated perinuclear germline compartments called Mutator foci are a key element of …

Germline Argonautes direct transcriptome surveillance within perinuclear membraneless
organelles called nuage. In C. elegans, a family of Vasa-related Germ Line Helicase (GLH) …