More than 3000 type II restriction endonucleases have been discovered. They recognize
short, usually palindromic, sequences of 4–8 bp and, in the presence of Mg2+, cleave the …

The 1952 observation of host-induced non-hereditary variation in bacteriophages by
Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that …

The known nucleoside triphosphate-dependent restriction enzymes are hetero-oligomeric
proteins that behave as molecular machines in response to their target sequences. They …

MspJI is a novel modification-dependent restriction endonuclease that cleaves at a fixed
distance away from the modification site. Here, we present the biochemical characterization …

This book offers an introduction to the theoretical and practical basis of genetic engineering,
gene cloning and molecular biology. All aspects of genetic engineering in the post-genomic …

The exponential growth of pathogen nucleic acid sequences available in public domain
databases has invited their direct use in pathogen detection, identification, and surveillance …

The mode of action of the bacterial ter cluster and TelA genes, implicated in natural
resistance to tellurite and other xenobiotic toxic compounds, pore-forming colicins and …

Using a unique microarray platform for cytosine methylation profiling, the DNA methylation
landscape of the human genome was monitored at more than 21 000 sites, including 79% of …

Neuron navigators (Navigators) are cytoskeletal-associated proteins important for neuron
migration, neurite growth, and axon guidance, but they also function more widely in other …

Abstract Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in
mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains …