Circadian rhythms are internal manifestations of the solar day that permit adaptations to
predictable environmental temporal changes. These~ 24-h rhythms are controlled by …

Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

Sleep disturbances are commonly observed in schizophrenia, including in chronic, early-
course, and first-episode patients. This has generated considerable interest, both in clinical …

The nearly ubiquitous expression of endogenous 24 h oscillations known as circadian
rhythms regulate the timing of physiological functions in the body. These intrinsic rhythms …

Sleep and circadian rhythm disruption (SCRD) is a common feature of schizophrenia, and is
associated with symptom severity and patient quality of life. It is commonly manifested as …

A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping
machinery known as the circadian clock (biological clock), which enables to anticipate …

A bstract Bipolar disorder (BD) is a neuropsychiatric illness defined by recurrent episodes of
mania/hypomania, depression and circadian rhythm abnormalities. Lithium is an effective …