Epigenetics and oxidative stress in aging

A Guillaumet-Adkins, Y Yañez… - Oxidative medicine …, 2017 - Wiley Online Library
Aging is a multifactorial process characterized by the progressive loss of physiological
functions, leading to an increased vulnerability to age‐associated diseases and finally to …

Causes of genome instability: the effect of low dose chemical exposures in modern society

SAS Langie, G Koppen, D Desaulniers… - …, 2015 - academic.oup.com
Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

AA Mills - Nature Reviews Cancer, 2010 - nature.com
The discovery that cancer can be governed above and beyond the level of our DNA
presents a new era for designing therapies that reverse the epigenetic state of a tumour cell …

Epigenetic modifications in prostate cancer

M Sugiura, H Sato, M Kanesaka… - … Journal of Urology, 2021 - Wiley Online Library
Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

[图书][B] Carotenoids: physical, chemical, and biological functions and properties

JT Landrum - 2009 - taylorfrancis.com
Carotenoids are of great interest due to their essential biological functions in both plants and
animals. However, the properties and functions of carotenoids in natural systems are …

The role of histone deacetylases in prostate cancer

A Abbas, S Gupta - Epigenetics, 2008 - Taylor & Francis
Epigenetic modifications play a key role in the patho-physiology of prostate cancer. Histone
deacetylases (HDACs) play major roles in prostate cancer progression. HDACs are part of a …

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

A Salminen, J Ojala, K Kaarniranta - Cellular and molecular life sciences, 2011 - Springer
Apoptosis is a vital component in the evolutionarily conserved host defense system.
Apoptosis is the guardian of tissue integrity by removing unfit and injured cells without …

DNA methylation and apoptosis resistance in cancer cells

E Hervouet, M Cheray, FM Vallette, PF Cartron - Cells, 2013 - mdpi.com
Apoptosis is a cell death programme primordial to cellular homeostasis efficiency. This
normal cell suicide program is the result of the activation of a cascade of events in response …

Aberrant DNA methylation and prostate cancer

S Majumdar, E Buckles, J Estrada… - Current …, 2011 - ingentaconnect.com
Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

DNA methylation in promoter region as biomarkers in prostate cancer

M Yang, JY Park - Cancer Epigenetics: Methods and Protocols, 2012 - Springer
The prostate gland is the most common site of cancer and the second leading cause of
cancer death in American men. Recent emerging molecular biological technologies help us …