Recent advances in biotechnology for heparin and heparan sulfate analysis

M Qiao, L Lin, K Xia, J Li, X Zhang, RJ Linhardt - Talanta, 2020 - Elsevier
Heparan sulfate (HS) is a class of linear, sulfated, anionic polysaccharides, called
glycosaminoglycans (GAGs), which present on the mammalian cell surfaces and …

Advances in heparin structural analysis by chromatography technologies

Y Ouyang, L Yi, L Qiu, Z Zhang - Se pu= Chinese Journal of …, 2023 - europepmc.org
肝素 (heparin, Hp) 是目前临床应用最为广泛的抗凝剂, 是由重复二糖单元组成的多硫酸化酸性
直链多糖. 低分子量肝素 (LMWHs) 是以肝素为原料, 经过化学或酶降解获得的相对分子质量 …

[HTML][HTML] 色谱技术在肝素结构分析中的研究进展

Y OUYANG, YI Lin, QIU Luyun… - Chinese Journal of …, 2023 - ncbi.nlm.nih.gov
肝素( heparin, Hp) 是目前临床应用最为广泛的抗凝剂, 是由重复二糖单元组成的多硫酸化
酸性直链多糖。 低分子量肝素( LMWHs) 是以肝素为原料, 经过化学或酶降解获得的相对分子 …

Analysis of heparinase derived LMWH products using a MHC 2D LC system linked to Q-TOF MS

L Chen, W Zhu, N Yan, Y Guo, L Yi, Y Ouyang… - … of Pharmaceutical and …, 2022 - Elsevier
Low molecular weight heparins (LMWHs), depolymerized from unfractionated heparin
(UFH), are widely used as anticoagulant drugs in clinic. The variable degradation methods …

State-of-the-Art Chromatographic and Mass Spectrometric Techniques in Heparin Structural Analysis

Y Ouyang, S Yang, W Wang, J Cui, Z Zhang - Journal of Pharmaceutical …, 2024 - Elsevier
Heparin is the most extensively used anticoagulant in clinical practice. It is a highly sulfated,
linear polysaccharide composed of repeating disaccharide units. As a member of the …

Non-anticoagulant low molecular weight heparins for pharmaceutical applications

Y Ouyang, Y Yu, F Zhang, J Chen, X Han… - Journal of medicinal …, 2019 - ACS Publications
Heparin is a polypharmacological agent with anticoagulant activity. Periodate oxidation of
the nonsulfated glucuronic acid residue results in non-anticoagulant heparin derivative …

Nowe kierunki badań i wyzwania w analizie leków heparynowych

R Sadowski, D Krysztofiak… - Wiadomości …, 2021 - yadda.icm.edu.pl
The complexity of the structure of heparin anticoagulants requires appropriate sample
preparation to be able to perform the analysis correctly. This stage of the analytical …