Excessive alcohol consumption is a leading cause of chronic liver disease in the Western
world. Alcohol-induced hepatotoxicity and oxidative stress are important mechanisms …

The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key
role in host defense against viral infection and tumor transformation. Recent evidence from …

Binge drinking, the most common form of alcohol consumption, is associated with increased
mortality and morbidity; yet, its biological consequences are poorly defined. Previous studies …

Alcohol is readily distributed throughout the body in the blood stream and crosses biological
membranes, which affect virtually all biological processes inside the cell. Excessive alcohol …

Alcohol abuse is a leading cause of liver disease characterized by liver inflammation, fatty
liver, alcoholic hepatitis, or liver cirrhosis. Immunomodulatory effects of alcohol on …

Background & Aims Alcohol is a primary cause of liver disease and an important co-
morbidity factor in other causes of liver disease. A common feature of progressive liver …

Hepatocellular carcinoma (HCC) is the most common liver cancer and a leading cause of
cancer-related mortality in the world. Hepatitis C virus (HCV) is a major etiologic agent of …

Activation of inflammatory signaling pathways is of central importance in the pathogenesis of
alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Recent studies …

The liver is the main target organ for hepatitis viruses and the vital organ for alcohol
metabolism. These two factors of viral hepatitis and alcohol abuse in combination can exert …

Human hepatocellular carcinoma (HCC) is an inflammation‐induced cancer, which is the
third‐leading cause of cancer mortality worldwide. We investigated the role of the …