Axenfeld–Rieger syndrome (ARS) is a rare autosomal dominant disorder, which
encompasses a range of congential malformations affecting the anterior segment of the eye …

Metastasis accounts for more than 90% of cancer related mortality, thus the most pressing
need in the field of oncology today is the ability to accurately predict future onset of …

Disorders of the anterior segment of the eye encompass a variety of clinical presentations
including aniridia, Axenfeld and Rieger anomalies, primary congenital glaucoma, Peters …

Purpose To analyze the contributions of cytochrome P4501B1 (CYP1B1) mutations to
primary congenital glaucoma (PCG) in Spanish patients. Methods We analyzed, by …

Pseudoexfoliation glaucoma (PEXG) is characterized by dysregulated extracellular matrix
(ECM) homeostasis that disrupts conventional outflow function and increases intraocular …

Primary congenital glaucoma (PCG) is one of the primary causes of blindness in children
and is characterized by congenital trabecular meshwork and anterior chamber angle …

Primary congenital glaucoma (PCG) is an autosomal recessive disorder in children due to
the abnormal development of the trabecular meshwork and the anterior chamber angle. With …

Importance Both primary and secondary forms of childhood glaucoma have many distinct
causative mechanisms, and in many cases a cause is not immediately clear. The broad …

Childhood glaucoma is an important cause of blindness world-wide. Eleven genes are
currently known to cause inherited forms of glaucoma with onset before age 20. While all the …

Purposes: Recent studies have suggested that loss-of-function mutations of the tunica intima
endothelial receptor tyrosine kinase (TEK) are responsible for approximately 5% of primary …