Concerning neuromodulation as treatment of neurological and neuropsychiatric disorder: Insights gained from selective targeting of the subthalamic nucleus, para …

A Ricci, E Rubino, GP Serra, Å Wallén-Mackenzie - Neuropharmacology, 2024 - Elsevier
Neuromodulation such as deep brain stimulation (DBS) is advancing as a clinical
intervention in several neurological and neuropsychiatric disorders, including Parkinson´ s …

[HTML][HTML] Deep brain stimulation of symptom-specific networks in Parkinson's disease

N Rajamani, H Friedrich, K Butenko, T Dembek… - Nature …, 2024 - nature.com
Abstract Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial
symptoms in patients with Parkinson's disease. Potentially, improving each symptom may …

Role of Prefrontal Cortex Circuitry in Maintaining Social Homeostasis

SH Lee, ZM Williams - Biological Psychiatry, 2024 - Elsevier
Abstract (250 words limit; unstructured) Homeostasis is a fundamental concept in biology
and ensures the stability of life by maintaining the constancy of physiological processes …

[HTML][HTML] Subthalamic and pallidal oscillations and their couplings reflect dystonia severity and improvements by deep brain stimulation

X Geng, Z Quan, R Zhang, G Zhu, Y Nie, S Wang… - Neurobiology of …, 2024 - Elsevier
Background Deep brain stimulation (DBS) targeting the globus pallidus internus (GPi) and
subthalamic nucleus (STN) is employed for the treatment of dystonia. Pallidal low-frequency …

A reproducible pipeline for parcellation of the anterior limb of the internal capsule

K Sretavan, H Braun, Z Liu, D Bullock… - Biological Psychiatry …, 2024 - Elsevier
Background The anterior limb of the internal capsule (ALIC) is a white matter structure
connecting the prefrontal cortex (PFC) to the brainstem, thalamus, and subthalamic nucleus …

[HTML][HTML] Deep brain stimulation of the subthalamic nucleus for Parkinson's disease: A network imaging marker of the treatment response

P Unadkat, A Vo, Y Ma, S Peng, N Nguyen… - Research …, 2024 - ncbi.nlm.nih.gov
Subthalamic nucleus deep brain stimulation (STN-DBS) alleviates motor symptoms of
Parkinson's disease (PD), thereby improving quality of life. However, quantitative brain …

[HTML][HTML] Network localization of pediatric lesion-induced dystonia

R Gelineau-Morel, N Dlamini, J Bruss, AL Cohen… - medRxiv, 2024 - ncbi.nlm.nih.gov
Objective: Dystonia is a movement disorder defined by involuntary muscle contractions
leading to abnormal postures or twisting and repetitive movements. Classically dystonia has …

[HTML][HTML] Spatiotemporally-specific cortical-subthalamic coupling differentiates aspects of speech performance

M Vissani, A Bush, WJ Lipski, P Fischer, C Neudorfer… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Speech provides a rich context for exploring human cortical-basal ganglia circuit function,
but direct intracranial recordings are rare. We recorded electrocorticographic signals in the …

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

TS Binns, RM Köhler, J Vanhoecke, M Chikermane… - bioRxiv, 2024 - biorxiv.org
Deep brain stimulation (DBS) is a brain circuit intervention that can modulate distinct neural
pathways for the alleviation of neurological symptoms in patients with brain disorders. In …

Ultrasound system for precise neuromodulation of human deep brain circuits

E Martin, M Roberts, IF Grigoras, O Wright, T Nandi… - bioRxiv, 2024 - biorxiv.org
Transcranial ultrasound stimulation (TUS) has emerged as a promising technique for non-
invasive neuromodulation, but current systems lack the precision to target deep brain …