Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
Renal autoregulation in health and disease
M Carlström, CS Wilcox… - Physiological …, 2015 - journals.physiology.org
Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …
Potassium channels in regulation of vascular smooth muscle contraction and growth
WF Jackson - Advances in Pharmacology, 2017 - Elsevier
Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …
KCNQ-encoded potassium channels as therapeutic targets
V Barrese, JB Stott, IA Greenwood - Annual review of …, 2018 - annualreviews.org
Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …
Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective
Potassium (K+) ion channel activity is an important determinant of vascular tone by
regulating cell membrane potential (MP). Activation of K+ channels leads to membrane …
regulating cell membrane potential (MP). Activation of K+ channels leads to membrane …
Downregulation of Kv7. 4 channel activity in primary and secondary hypertension
Background—Voltage-gated potassium (K+) channels encoded by KCNQ genes (Kv7
channels) have been identified in various rodent and human blood vessels as key …
channels) have been identified in various rodent and human blood vessels as key …
Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels
A Martelli, L Testai, MC Breschi, K Lawson… - Pharmacological …, 2013 - Elsevier
Hydrogen sulphide (H2S) has been recently hypothesized to be an endogenous adipocyte-
derived relaxing factor, evoking vasorelaxation of conductance and resistance vessels …
derived relaxing factor, evoking vasorelaxation of conductance and resistance vessels …
Role of myosin light chain kinase and myosin light chain phosphatase in the resistance arterial myogenic response to intravascular pressure
WC Cole, DG Welsh - Archives of biochemistry and biophysics, 2011 - Elsevier
The intrinsic ability of vascular smooth muscle cells (VSMCs) within arterial resistance
vessels to respectively contract and relax in response to elevation and reduction of …
vessels to respectively contract and relax in response to elevation and reduction of …
Expression and function of the K+ channel KCNQ genes in human arteries
BACKGROUND AND PURPOSE KCNQ‐encoded voltage‐gated potassium channels (Kv7)
have recently been identified as important anti‐constrictor elements in rodent blood vessels …
have recently been identified as important anti‐constrictor elements in rodent blood vessels …