[HTML][HTML] Tertiary lymphoid structures and B cells: An intratumoral immunity cycle
WH Fridman, M Meylan, G Pupier, A Calvez… - Immunity, 2023 - cell.com
The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies
Anti-CTLA-4 antibodies have successfully elicited durable tumor regression in the clinic;
however, long-term benefit is limited to a subset of patients for select cancer indications. The …
however, long-term benefit is limited to a subset of patients for select cancer indications. The …
Heterogeneity of tertiary lymphoid structures in cancer
X You, K Koop, A Weigert - Frontiers in Immunology, 2023 - frontiersin.org
The success of immunotherapy approaches, such as immune checkpoint blockade and
cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the …
cellular immunotherapy with genetically modified lymphocytes, has firmly embedded the …
Lung tumor–infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response
AG Dykema, J Zhang, LS Cheung, S Connor… - Science …, 2023 - science.org
Regulatory T cells (Treg) are conventionally viewed as suppressors of endogenous and
therapy-induced antitumor immunity; however, their role in modulating responses to immune …
therapy-induced antitumor immunity; however, their role in modulating responses to immune …
[HTML][HTML] Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significance
X Zou, X Lin, H Cheng, Y Chen, R Wang… - … for ImmunoTherapy of …, 2023 - ncbi.nlm.nih.gov
Background Tumor-associated tertiary lymphoid structures (TLSs) are functional immune-
responsive niches that are not fully understood in pancreatic ductal adenocarcinoma …
responsive niches that are not fully understood in pancreatic ductal adenocarcinoma …
CD8+ T cell priming that is required for curative intratumorally anchored anti-4-1BB immunotherapy is constrained by Tregs
Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves
antitumor immune responses in preclinical studies, clinical success has been limited by on …
antitumor immune responses in preclinical studies, clinical success has been limited by on …
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Y Zhang, M Xu, Y Ren, Y Ba, S Liu, A Zuo, H Xu… - Molecular Cancer, 2024 - Springer
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function
similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an …
similarly to secondary lymphoid organs (SLOs). While TLS is generally associated with an …
Advances in efficacy prediction and monitoring of neoadjuvant immunotherapy for non-small cell lung cancer
Y Wang, S Huang, X Feng, W Xu, R Luo, Z Zhu… - Frontiers in …, 2023 - frontiersin.org
The use of immune checkpoint inhibitors (ICIs) has become mainstream in the treatment of
non-small cell lung cancer (NSCLC). The idea of harnessing the immune system to fight …
non-small cell lung cancer (NSCLC). The idea of harnessing the immune system to fight …
HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival …
AI Bravo, M Aris, M Panouillot, M Porto… - Frontiers in …, 2023 - frontiersin.org
Introduction Tissue biomarkers that aid in identifying cutaneous melanoma (CM) patients
who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor …
who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor …
Tertiary lymphoid structures in cancer: maturation and induction
Y Chen, Y Wu, G Yan, G Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral
non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated TLS serves …
non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated TLS serves …