The Gag proteins of HIV-1, like those of other retroviruses, are necessary and sufficient for
the assembly of virus-like particles. The roles played by HIV-1 Gag proteins during the life …

Enveloped viruses mature by budding at cellular membranes. It has been generally thought
that this process is driven by interactions between the viral transmembrane proteins and the …

HIV-1 and other retroviruses exit infected cells by budding from the plasma membrane, a
process requiring membrane fission. The primary late assembly (L) domain in the p6 region …

Retroviral Gag proteins encode sequences, termed late domains, which facilitate the final
stages of particle budding from the plasma membrane. We report here that interactions …

VP40, the putative matrix protein of both Ebola and Marburg viruses, possesses a conserved
proline-rich motif (PY motif) at its N terminus. We demonstrate that the VP40 protein can …

Domains have been identified in the Gag proteins of a number of retroviruses, and in the
matrix proteins of the rhabdoviruses and filoviruses, that play a critical role in the pinching off …

A necessary step in the genesis of an extracellular enveloped virus particle is the formation
of an outer virion membrane. Often, virion membrane is derived from host cell membranes …

Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function
of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the “late” …

Many enveloped viruses complete their replication cycle by forming vesicles that bud from
the plasma membrane. Some viruses encode “late”(L) domain motifs that are able to hijack …

The matrix (M) protein of rhabdoviruses has been shown to play a key role in virus assembly
and budding; however, the precise mechanism by which M mediates these processes …