Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Functionalized fullerenes have shown interesting biomedical applications as potential
phototherapeutic agents. The hydrophobic carbon sphere of fullerene C 60 can be …

Existing antibacterial agents can be categorized into two generations, but bacterial
insensitivity towards both of these classes poses a serious public health challenge …

We live in the era of antibiotic resistance, and this problem will progressively worsen if no
new solutions emerge. In particular, Gram-negative pathogens present both biological and …

Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …

The double-membrane cell envelope of Gram-negative bacteria is a formidable barrier to
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …

The COVID-19 pandemic has refocused attention worldwide on the dangers of infectious
diseases, in terms of both global health and the effects on the world economy. Even in high …

Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

In an era where the pipeline of new antibiotic development is drying up, the continuous rise
of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine …