Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

Cancer formation is a complex and highly regulated multi-step process which is highly
dependent of its environment, from the tissue to the patient. This complexity implies the …

AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

In the biomedical area, the interdisciplinary field of nanotechnology has the potential to bring
numerous unique applications, including better tactics for cancer detection, diagnosis, and …

A wide variety of agents activate AMPK, but in many cases the mechanisms remain unclear.
We generated isogenic cell lines stably expressing AMPK complexes containing AMP …

AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which
coordinates metabolic pathways and thus balances nutrient supply with energy demand …

Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …