K63 ubiquitination in immune signaling
C Madiraju, JP Novack, JC Reed, S Matsuzawa - Trends in Immunology, 2022 - cell.com
Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …
evidence has shown that the control of multiple immune functions, including chronic …
Non-lysine ubiquitylation: Doing things differently
IR Kelsall - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus
Z Wu, LA Berlemann, V Bader, DA Sehr… - The EMBO …, 2022 - embopress.org
Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways
that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research …
that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research …
NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
N Furthmann, V Bader, L Angersbach, A Blusch… - Nature …, 2023 - nature.com
NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in
innate immune signaling, cell death regulation and host-pathogen interactions. Here we …
innate immune signaling, cell death regulation and host-pathogen interactions. Here we …
Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
Pancreatic ductal adenocarcinoma (PDA) is an inherently immune cell deprived tumor,
characterized by desmoplastic stroma and suppressive immune cells. Here we …
characterized by desmoplastic stroma and suppressive immune cells. Here we …
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling
The NF-κB essential modulator NEMO is the core regulatory component of the inhibitor of κB
kinase complex, which is a critical checkpoint in canonical NF-κB signaling downstream of …
kinase complex, which is a critical checkpoint in canonical NF-κB signaling downstream of …
OTUD1 deubiquitinase regulates NF-κB-and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways
Deubiquitinating enzymes (DUBs) regulate numerous cellular functions by removing
ubiquitin modifications. We examined the effects of 88 human DUBs on linear ubiquitin …
ubiquitin modifications. We examined the effects of 88 human DUBs on linear ubiquitin …
The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs)
T So - International Immunology, 2022 - academic.oup.com
The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are
intracellular signaling adaptors and control diverse signaling pathways mediated not only by …
intracellular signaling adaptors and control diverse signaling pathways mediated not only by …
The Met1-linked ubiquitin machinery in inflammation and infection
BK Fiil, M Gyrd-Hansen - Cell Death & Differentiation, 2021 - nature.com
Ubiquitination is an essential post-translational modification that regulates most cellular
processes. The assembly of ubiquitin into polymeric chains by E3 ubiquitin ligases underlies …
processes. The assembly of ubiquitin into polymeric chains by E3 ubiquitin ligases underlies …
Ubiquitin-dependent and-independent functions of OTULIN in cell fate control and beyond
N Weinelt, SJL van Wijk - Cell Death & Differentiation, 2021 - nature.com
Ubiquitination, and its control by deubiquitinating enzymes (DUBs), mediates protein
stability, function, signaling and cell fate. The ovarian tumor (OTU) family DUB OTULIN …
stability, function, signaling and cell fate. The ovarian tumor (OTU) family DUB OTULIN …