Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies

ROS Soares, DM Losada, MC Jordani, P Évora… - International journal of …, 2019 - mdpi.com
Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

Cellular pathophysiology of ischemic acute kidney injury

JV Bonventre, L Yang - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …

[HTML][HTML] Pathophysiology of acute kidney injury

DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Immune cells in experimental acute kidney injury

HR Jang, H Rabb - Nature Reviews Nephrology, 2015 - nature.com
Acute kidney injury (AKI) prolongs hospital stay and increases mortality in various clinical
settings. Ischaemia–reperfusion injury (IRI), nephrotoxic agents and infection leading to …

Pathophysiology of ischemic acute kidney injury

AA Sharfuddin, BA Molitoris - Nature Reviews Nephrology, 2011 - nature.com
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …

[HTML][HTML] The severity of acute kidney injury predicts progression to chronic kidney disease

LS Chawla, RL Amdur, S Amodeo, PL Kimmel… - Kidney international, 2011 - Elsevier
Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease
(CKD). We tested whether patients who survive AKI and are at higher risk for CKD …

[HTML][HTML] Cellular and molecular pathways of renal repair after acute kidney injury

S Kumar - Kidney international, 2018 - Elsevier
The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction

LSF Konijnenberg, P Damman… - Cardiovascular …, 2020 - academic.oup.com
Early mechanical reperfusion of the epicardial coronary artery by primary percutaneous
coronary intervention (PCI) is the guideline-recommended treatment for ST-elevation …

Update on mechanisms of ischemic acute kidney injury

P Devarajan - Journal of the American Society of Nephrology, 2006 - journals.lww.com
Acute renal failure (ARF), classically defined as an abrupt decrease in kidney function that
leads to accumulation of nitrogenous wastes such as blood urea nitrogen and creatinine, is …

Global consequences of liver ischemia/reperfusion injury

C Nastos, K Kalimeris, N Papoutsidakis… - Oxidative medicine …, 2014 - Wiley Online Library
Liver ischemia/reperfusion injury has been extensively studied during the last decades and
has been implicated in the pathophysiology of many clinical entities following hepatic …