Geroscience puts mechanisms of aging as a driver of the most common age-related
diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of …

Major depressive disorder (MDD) presents different clinical features in women and men,
with women being more affected and responding differently to antidepressant treatment …

Compelling evidence demonstrates that some individuals suffering from major depressive
disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation …

Background The dentate gyrus (DG) has been implicated in the pathophysiology of
depression. Many studies have revealed the cellular types, neural circuits, and …

Several factors may affect response to treatment in Major Depressive Disorder (MDD)
including immune/inflammatory alterations and regional brain volumes, particularly in …

Low‐grade inflammation is considered as a pathophysiological mechanism in a subtype of
patients with major depressive disorder (MDD). Anti‐inflammatory drugs have shown …

Aging is a dynamic process that requires a continuous response and adaptation to internal
and external stimuli over the life course. This eventually results in people aging differently …

Depression is one of the most common mental disorders and is mainly characterized by low
mood or lack of interest and pleasure. It can be accompanied by varying degrees of …

Sex hormones have biological effects on inflammation, and these might contribute to the sex-
specific features of depression. C-reactive protein (CRP) is the most widely used …

Seasonal rhythms affect the immune system. Evidence supports the involvement of immuno-
inflammatory mechanisms in bipolar disorder (BD), with the neutrophil to lymphocyte ratio …