The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …

Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …

INTRODUCTION Protein kinases mediate many cell signaling processes. Central to their
physiological function is the regulation of their binding and enzymatic activities, which is …

Many human malignancies are associated with aberrant regulation of protein or lipid
kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein …

Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly
organized internal architecture. A single hydrophobic F-helix serves as a central scaffold for …

Post-translational modifications of proteins and the domains that recognize these
modifications have central roles in creating a highly dynamic relay system that reads and …

Proteins display a hierarchy of structural features at primary, secondary, tertiary, and higher-
order levels, an organization that guides our current understanding of their biological …

SRRM2 is a nuclear-speckle marker containing multiple disordered domains, whose
dysfunction is associated with several human diseases. Using mainly EGFP-SRRM2 knock …

Eukaryotic protein kinases are key regulators of cell processes. Comparison of the structures
of protein kinase domains, both alone and in complexes, allows generalizations to be made …

Signal transduction can be defined as the coordinated relay of messages derived from
extracellular cues to intracellular effectors. More simply put, information received on the cell …