[HTML][HTML] Macrophage diversity in cancer revisited in the era of single-cell omics
RY Ma, A Black, BZ Qian - Trends in immunology, 2022 - cell.com
Tumor-associated macrophages (TAMs) have multiple potent functions in cancer and, thus,
represent important therapeutic targets. These diverse functions highlight the heterogenous …
represent important therapeutic targets. These diverse functions highlight the heterogenous …
Therapeutic targeting of the tumor microenvironment
L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …
promising approach for cancer treatment in recent years due to the critical roles of the TME …
Nasopharyngeal carcinoma: an evolving paradigm
The past three decades have borne witness to many advances in the understanding of the
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …
[HTML][HTML] Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem
W Luo - Theranostics, 2023 - ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …
Efficacy, safety, and correlative biomarkers of toripalimab in previously treated recurrent or metastatic nasopharyngeal carcinoma: a phase II clinical trial (POLARIS-02 …
FH Wang, XL Wei, J Feng, Q Li, N Xu, XC Hu… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE As yet, no checkpoint inhibitor has been approved to treat nasopharyngeal
carcinoma (NPC). This study was aimed to evaluate the antitumor activity, safety, and …
carcinoma (NPC). This study was aimed to evaluate the antitumor activity, safety, and …
[HTML][HTML] Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
The development of combination immunotherapy based on the mediation of regulatory
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …
[HTML][HTML] Unraveling B cell trajectories at single cell resolution
D Morgan, V Tergaonkar - Trends in immunology, 2022 - cell.com
During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …
[HTML][HTML] Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma
The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using
single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients' …
single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients' …
[HTML][HTML] Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
[HTML][HTML] Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment
responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 …
responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 …