The roles and regulation of the KLF5 transcription factor in cancers
Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …
that KLF5 regulates the expression of a large number of new target genes and participates …
[HTML][HTML] The emerging role of super enhancer-derived noncoding RNAs in human cancer
Y Wang, H Nie, X He, Z Liao, Y Zhou, J Zhou, C Ou - Theranostics, 2020 - ncbi.nlm.nih.gov
Super enhancers (SEs) are large clusters of adjacent enhancers that drive the expression of
genes which regulate cellular identity; SE regions can be enriched with a high density of …
genes which regulate cellular identity; SE regions can be enriched with a high density of …
Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer
Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids
Y Mao, W Wang, J Yang, X Zhou, Y Lu, J Gao… - Protein & …, 2024 - academic.oup.com
Colorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic
options is a pressing issue that needs to be addressed. Here, we established human CRC …
options is a pressing issue that needs to be addressed. Here, we established human CRC …
Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma
This study investigates aberrant DNA methylations as potential diagnosis and prognosis
markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced …
markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced …
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence
Esophageal squamous cell carcinomas (ESCCs) harbor recurrent chromosome 3q
amplifications that target the transcription factor SOX2. Beyond its role as an oncogene in …
amplifications that target the transcription factor SOX2. Beyond its role as an oncogene in …
Current methods of post-translational modification analysis and their applications in blood cancers
Simple Summary This review discusses current techniques used to study post-translational
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
protein modifications (PTMs) and their contribution to blood cancer research. Blood cancer …
Super-enhancers complexes zoom in transcription in cancer
MT Wang, QY Chen, SJ Wang, H Xie, J Liu… - Journal of Experimental …, 2023 - Springer
Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …
Core transcriptional regulatory circuitries in cancer
Y Chen, L Xu, RYT Lin, M Müschen, HP Koeffler - Oncogene, 2020 - nature.com
Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a
combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed …
combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed …
KLF5 promotes tumor progression and parp inhibitor resistance in ovarian cancer
Y Wu, S Chen, Y Shao, Y Su, Q Li, J Wu… - Advanced …, 2023 - Wiley Online Library
One major characteristic of tumor cells is the aberrant activation of epigenetic regulatory
elements, which remodel the tumor transcriptome and ultimately promote cancer …
elements, which remodel the tumor transcriptome and ultimately promote cancer …