Regional limb perfusion (RLP) is a technique widely used for the treatment of limb infections
in horses. The objective is to deliver high concentrations of an antimicrobial to a focal region …

Intravenous regional limb perfusions (RLP) are widely used in equine medicine to treat
distal limb infections, including synovial sepsis. RLPs are generally deemed successful if the …

Orthopaedic infections, including synovial sepsis, osteomyelitis and infection of orthopaedic
implants are common in equine medicine. Infections can be caused by haematogenous …

Equine antimicrobial therapy has advanced over time with the availability of increasing
pharmacokinetic and pharmacodynamic studies in horses, allowing for greater evidence …

Objective To determine synovial butorphanol concentrations and mechanical nociceptive
threshold (MNT) changes after butorphanol intravenous regional limb perfusion (IVRLP) …

This chapter provides specific alterations that occur with musculoskeletal disease. White
blood cell counts and cell differentials in neonatal foals are comparable to adult horses and …

Regional limb perfusion of medications was first described by August Karl Bier in 1908 and
was initially used to describe the technique of exsanguinating the upper extremity and …

The objective of this study was to determine the pharmacokinetics of meropenem in horses
after intravenous (IV) administration. A single IV dose of meropenem was administered to six …

Septic synovitis is a critical orthopedic condition in horses. Early intervention is key, with
antibiotic therapy typically initiated prior to culture and susceptibility reports becoming …

Intravenous regional limb perfusion (RLP) has been used extensively in equine and human
practice to deliver high doses of antimicrobials to bones, joints and the soft tissues in the …