Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …

Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell
proliferation and differentiation, as well as tissue remodeling, are mediated in part by …

The clearance of damaged myelin sheaths is critical to ensure functional recovery from
neural injury. Here we show a previously unidentified role for microvessels and their lining …

The wound healing process that occurs after spinal cord injury is critical for maintaining
tissue homeostasis and limiting tissue damage, but eventually results in a scar-like …

After spinal cord injury, macrophages can exert either beneficial or detrimental effects
depending on their phenotype. Aside from their critical role in inflammatory responses …