Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
The biology of regeneration failure and success after spinal cord injury
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
Microglia coordinate cellular interactions during spinal cord repair in mice
Traumatic spinal cord injury (SCI) triggers a neuro-inflammatory response dominated by
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …
tissue-resident microglia and monocyte derived macrophages (MDMs). Since activated …
Current advancements in spinal cord Injury Research—glial scar formation and neural regeneration
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …
Macrophage biology in the peripheral nervous system after injury
RE Zigmond, FD Echevarria - Progress in neurobiology, 2019 - Elsevier
Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …
Acute spinal cord injury: Pathophysiology and pharmacological intervention
Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
The origin, fate, and contribution of macrophages to spinal cord injury pathology
LM Milich, CB Ryan, JK Lee - Acta neuropathologica, 2019 - Springer
Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell
proliferation and differentiation, as well as tissue remodeling, are mediated in part by …
proliferation and differentiation, as well as tissue remodeling, are mediated in part by …
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
The clearance of damaged myelin sheaths is critical to ensure functional recovery from
neural injury. Here we show a previously unidentified role for microvessels and their lining …
neural injury. Here we show a previously unidentified role for microvessels and their lining …
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord
LM Milich, JS Choi, C Ryan, SR Cerqueira… - Journal of Experimental …, 2021 - rupress.org
The wound healing process that occurs after spinal cord injury is critical for maintaining
tissue homeostasis and limiting tissue damage, but eventually results in a scar-like …
tissue homeostasis and limiting tissue damage, but eventually results in a scar-like …
Macrophage phagocytosis after spinal cord injury: when friends become foes
After spinal cord injury, macrophages can exert either beneficial or detrimental effects
depending on their phenotype. Aside from their critical role in inflammatory responses …
depending on their phenotype. Aside from their critical role in inflammatory responses …