From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

[HTML][HTML] Epidemiology of non-alcoholic and alcoholic fatty liver diseases

S Mitra, A De, A Chowdhury - Translational gastroenterology and …, 2020 - ncbi.nlm.nih.gov
Liver diseases are fast emerging as global health priorities. Fatty liver is described in the
setting of non-alcoholic fatty liver disease (NAFLD) as well as alcoholic liver disease (ALD) …

Non-alcoholic fatty liver disease–a global public health perspective

ZM Younossi - Journal of hepatology, 2019 - Elsevier
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence
of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of …

[HTML][HTML] From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world

D Dimitroulis, C Damaskos, S Valsami… - World journal of …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy and the third
cause of cancer-related death in the Western Countries. The well-established causes of …

Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers

Y Wang, B Deng - Cancer and Metastasis Reviews, 2023 - Springer
Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of
cancer-related death. The biological process of HCC is complex, with multiple factors …

Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies

J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …

Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy

Y Zhao, TWH Shuen, TB Toh, XY Chan, M Liu, SY Tan… - Gut, 2018 - gut.bmj.com
Objective As the current therapeutic strategies for human hepatocellular carcinoma (HCC)
have been proven to have limited effectiveness, immunotherapy becomes a compelling way …

Why bile acids are so important in non-alcoholic fatty liver disease (NAFLD) progression

A Gottlieb, A Canbay - Cells, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a complex disease, affecting not just the liver,
but also all other organs in the body. Despite an increasing amount of people worldwide …

Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies

N Wang, S Wang, MY Li, B Hu, L Liu… - … in medical oncology, 2018 - journals.sagepub.com
The poor clinical outcome of hepatocellular carcinoma (HCC) patients is ascribed to the
resistance of HCC cells to traditional treatments and tumor recurrence after curative …

[HTML][HTML] The global epidemiology of nonalcoholic steatohepatitis (NASH) and associated risk factors–A targeted literature review

JF Dufour, R Scherer, MM Balp, SJ McKenna… - … and Metabolic Science, 2021 - Elsevier
Background There is a wide variation across studies in the reported prevalence of
nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). A …