Secreted proteases: A new insight in the pathogenesis of extraintestinal pathogenic Escherichia coli

R Tapader, S Basu, A Pal - International Journal of Medical Microbiology, 2019 - Elsevier
Bacterial secreted proteases are the key factors that increase the virulence potential of
different pathogens. Extraintestinal pathogenic E. coli (ExPEC) is a distinct pathotype that …

High frequency of hybrid Escherichia coli strains with combined Intestinal Pathogenic Escherichia coli (IPEC) and Extraintestinal Pathogenic Escherichia coli …

BA Lindstedt, MD Finton, D Porcellato… - BMC infectious diseases, 2018 - Springer
Abstract Background Classification of pathogenic Escherichia coli (E. coli) has traditionally
relied on detecting specific virulence associated genes (VAGs) or combinations thereof. For …

Role of mucus-bacteria interactions in Enterotoxigenic Escherichia coli (ETEC) H10407 virulence and interplay with human microbiome

T Sauvaitre, J Van Landuyt, C Durif… - npj Biofilms and …, 2022 - nature.com
The intestinal mucus layer has a dual role in human health constituting a well-known
microbial niche that supports gut microbiota maintenance but also acting as a physical …

The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins

MF Haurat, NE Scott, G Di Venanzio, J Lopez… - MBio, 2020 - Am Soc Microbiol
Glycans decorate proteins and affect their biological function, including protection against
proteolytic degradation. However, pathogenic, and commensal bacteria have evolved …

YghJ, the secreted metalloprotease of pathogenic E. coli induces hemorrhagic fluid accumulation in mouse ileal loop

R Tapader, D Bose, A Pal - Microbial pathogenesis, 2017 - Elsevier
YghJ, also known as SslE (Secreted and surface associated lipoprotein) is a cell surface
associated and secreted lipoprotein harbouring M60 metalloprotease domain. Though the …

[PDF][PDF] The glycoprotease CpaA secreted by medically relevant Acinetobacter species targets multiple O-linked host glycoproteins. mBio 11: e02033-20

MF Haurat, NE Scott, G Di Venanzio, J Lopez… - …, 2020 - minerva-access.unimelb.edu.au
Glycans decorate proteins and affect their biological function, including protection against
proteolytic degradation. However, pathogenic, and commensal bacteria have evolved …

[HTML][HTML] M60-like metalloprotease domain of the Escherichia coli YghJ protein forms amyloid fibrils

MV Belousov, SA Bondarev, AO Kosolapova… - PLoS …, 2018 - journals.plos.org
Amyloids are protein fibrils with a characteristic spatial structure. Amyloids were long
perceived as the pathogens involved in a set of lethal diseases in humans and animals. In …

Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1

N Nag, T Ray, R Tapader, A Gope, R Das, E Mahapatra… - Iscience, 2024 - cell.com
We have purified Peptidase M84 from Bacillus altitudinis in an effort to isolate anticancer
proteases from environmental microbial isolates. This metallo-protease had no discernible …

SslE (YghJ), a cell-associated and secreted lipoprotein of neonatal septicemic Escherichia coli, induces Toll-like receptor 2-dependent macrophage activation and …

R Tapader, D Bose, P Dutta, S Das, A Pal - Infection and Immunity, 2018 - Am Soc Microbiol
SslE (YghJ), a cell surface-associated and secreted lipoprotein, was identified as a potential
vaccine candidate for extraintestinal pathogenic Escherichia coli, providing nearly complete …

Linking inherent O-linked protein glycosylation of yghJ to increased antigen potential

M Thorsing, TJ Krogh, L Vitved, A Nawrocki… - Frontiers in Cellular …, 2021 - frontiersin.org
Enterotoxigenic Escherichia coli (ETEC) is a WHO priority pathogen and vaccine target
which causes infections in low-income and middle-income countries, travelers visiting …