Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Protein fusion tags are indispensible tools used to improve recombinant protein expression
yields, enable protein purification, and accelerate the characterization of protein structure …

The glutathione transferases (GSTs; also known as glutathione S-transferases) are major
phase II detoxification enzymes found mainly in the cytosol. In addition to their role in …

A very fast empirical method is presented for structure‐based protein pKa prediction and
rationalization. The desolvation effects and intra‐protein interactions, which cause variations …

Cysteine thiols are among the most reactive functional groups in proteins, and their pairing
in disulfide linkages is a common post-translational modification in proteins entering the …

Protein disulphide bonds are formed in the endoplasmic reticulum of eukaryotic cells and
the periplasmic space of prokaryotic cells. The main pathways that catalyse the formation of …

During the maturation of extracellular proteins, disulfide bonds that chemically cross-link
specific cysteines are often added to stabilize a protein or to join it covalently to other …

Thioredoxin —a fold for all reasons: Structure Skip to Main Content Advertisement Structure
This journal offers authors two options (open access or subscription) to publish research …

Thioredoxins are ubiquitous antioxidant enzymes that play important roles in many health-
related cellular processes. As such, the fundamental knowledge of how these enzymes work …

Examination of a protein's structural 'neighbors' can reveal distant evolutionary relationships
that are otherwise undetectable, and perhaps suggest unsuspected functional properties. In …