The sodium/iodide symporter (NIS): molecular physiology and preclinical and clinical applications
S Ravera, A Reyna-Neyra, G Ferrandino… - Annual review of …, 2017 - annualreviews.org
Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …
Hypothalamus‐pituitary‐thyroid axis
TM Ortiga‐Carvalho, MI Chiamolera… - Comprehensive …, 2011 - Wiley Online Library
The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …
Thyroid hormone biosynthesis and release
DP Carvalho, C Dupuy - Molecular and cellular endocrinology, 2017 - Elsevier
Abstract Thyroid hormones (TH) 3, 5, 3′, 5'-tetraiodothyronine or thyroxine (T4) and 3, 5, 3'-
triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur …
triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur …
The Na+/I− Symporter (NIS): Mechanism and Medical Impact
C Portulano, M Paroder-Belenitsky… - Endocrine …, 2014 - academic.oup.com
Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …
The sodium/iodide symporter (NIS): characterization, regulation, and medical significance
Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …
Immunohistochemical profile of the sodium/iodide symporter in thyroid, breast, and other carcinomas using high density tissue microarrays and conventional sections
IL Wapnir, M Van De Rijn, K Nowels… - The Journal of …, 2003 - academic.oup.com
Extrathyroidal cancers could potentially be targeted with 131I, if the Na+/I− symporter (NIS)
were functional. Using immunohistochemical methods we probed 1278 human samples with …
were functional. Using immunohistochemical methods we probed 1278 human samples with …
The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid
A Bizhanova, P Kopp - Endocrinology, 2009 - academic.oup.com
Thyroid hormones are essential for normal development and metabolism. Thyroid hormone
biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen …
biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen …
The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeutics
T Kogai, GA Brent - Pharmacology & therapeutics, 2012 - Elsevier
Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …
[HTML][HTML] Werner and Ingbar's the thyroid: a fundamental and clinical text
P Kopp, DS Cooper, LE Braverman - 2005 - doctorlib.info
Thyroid hormone biosynthesis, storage, and secretion require a series of highly regulated
steps. Iodide, the rate-limiting substrate for thyroid hormone synthesis, is actively transported …
steps. Iodide, the rate-limiting substrate for thyroid hormone synthesis, is actively transported …
The TSH receptor reveals itself
T Davies, R Marians, R Latif - The Journal of clinical …, 2002 - Am Soc Clin Investig
The thyrotropin receptor (TSHR), one of the primary antigens in autoimmune thyroid
disease, is a target of both antigen-specific T cells and antibodies in patients with this …
disease, is a target of both antigen-specific T cells and antibodies in patients with this …