Liver diseases related complications represent a significant source of morbidity and mortality
worldwide, creating a substantial economic burden. Oxidative stress, excessive …

There are numerous prescription drugs and non-prescription drugs that cause drug-induced
liver injury (DILI), which is the main cause of liver disease in humans around the globe. Its …

High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be
simply an architectural protein due to its DNA‐binding ability, evidence from the last decade …

Purpose Capsaicin (8-methyl-N-geranyl-6-nonamide; CAP) is an alkaloid isolated from chili
peppers, which has complex pharmacological properties, including beneficial effects against …

Drug‐induced liver injury (DILI) refers to adverse reactions to small chemical compounds,
biological agents, and medical products. These reactions can manifest as acute or chronic …

The first description of the medical use of licorice appeared in “Shennong Bencao Jing”, one
of the well-known Chinese herbal medicine classic books dated back to 220–280 AD. As …

High-mobility group box 1 (HMGB1) is an abundant architectural chromosomal protein that
has multiple biologic functions: gene transcription, DNA replication, DNA-damage repair …

Various human disorders are cured by the use of licorice, a key ingredient of herbal
remedies. Glycyrrhizic acid (GL), a triterpenoid glycoside, is the aqueous extract from licorice …

Acetaminophen (APAP) hepatotoxicity remains the leading cause of drug-induced liver
injury due to the lack of safe and effective therapeutic agents. Berberine (BBR) is a natural …

Previous studies have shown that silymarin protects against various types of drug-induced
liver injury, but whether the protective mechanism of silymarin against acetaminophen …