Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from
opposing spindle poles, is the configuration that best ensures equal partitioning of the …

Precise regulation of kinetochore–microtubule attachments is essential for successful
chromosome segregation. Central to this regulation is Aurora B kinase, which …

Accurate chromosome segregation requires the perfect spatiotemporal rearrangement of the
cellular cytoskeleton. Isolated more than two decades ago from Drosophila, Aurora A is a …

It is well established that Aurora kinases perform critical functions during mitosis. It has
become increasingly clear that the Aurora kinases also perform a myriad of non-mitotic …

The Aurora kinases are essential regulators of mitosis in eukaryotes. In somatic cell
divisions of higher eukaryotes, the paralogs Aurora kinase A (AurA) and Aurora kinase B …

Lung cancer is one of the most aggressive malignancies, classified into two major
histological subtypes: non-small cell lung cancer (NSCLC), that accounts for about 85% of …

Simple Summary Lung cancer has remained one of the major causes of death worldwide.
Thus, a more effective treatment approach is essential, such as the inhibition of specific …