Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states
such as diabetes, macrophage plasticity is impaired, and macrophages remain in a …

The immune microenvironment plays a critical role in regulating skin wound healing.
Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in …

Non-healing wounds in Type 2 Diabetes (T2D) patients represent the most common cause
of amputation in the US, with an associated 5-year mortality of nearly 50%. Our lab has …

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

Abstract Leaf of Nelumbo nucifera Gaertn.(N. nucifera) has been widely used as the main
ingredient in lipid-lowering herbal teas and some prescriptions in China due to their …

The etiology of most autoimmune diseases remains unknown; however, shared among them
is a disruption of immunoregulation. Prostaglandin lipid signaling molecules possess …

Skin wound repair is essential for organismal survival and failure of which leads to non‐
healing wounds, a leading health issue worldwide. However, mechanistic understanding of …

Aberrant subchondral bone architecture is a crucial driver of the pathological progression of
osteoarthritis, coupled with increased sensory innervation. The sensory PGE2/EP4 pathway …