Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer
RL Bitting, AJ Armstrong - Endocrine-related cancer, 2013 - erc.bioscientifica.com
Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …
women, respectively. Here, we focus on the known biology of acquired resistance to …
[HTML][HTML] The molecular and cellular origin of human prostate cancer
JR Packer, NJ Maitland - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Prostate cancer is the most commonly diagnosed male malignancy. Despite compelling
epidemiology, there are no definitive aetiological clues linking development to frequency …
epidemiology, there are no definitive aetiological clues linking development to frequency …
Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program
Understanding the biology of prostate cancer metastasis has been limited by the lack of
tissue for study. We studied the clinical data, distribution of prostate cancer involvement …
tissue for study. We studied the clinical data, distribution of prostate cancer involvement …
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
H Tanaka, E Kono, CP Tran, H Miyazaki, J Yamashiro… - Nature medicine, 2010 - nature.com
The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a
lethal event of uncertain molecular etiology. Comparing gene expression in isogenic …
lethal event of uncertain molecular etiology. Comparing gene expression in isogenic …
Androgen receptor–and E2F-1–targeted thymoquinone therapy for hormone-refractory prostate cancer
AO Kaseb, K Chinnakannu, D Chen, A Sivanandam… - Cancer research, 2007 - AACR
Relapse of prostate cancer after androgen ablation therapy is hormone-refractory, with
continued tumor growth being dependent on the androgen receptor (AR). E2F-1, a regulator …
continued tumor growth being dependent on the androgen receptor (AR). E2F-1, a regulator …
miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation
MicroRNAs (miRNA) have been globally profiled in cancers but there tends to be poor
agreement between studies including in the same cancers. In addition, few putative miRNA …
agreement between studies including in the same cancers. In addition, few putative miRNA …
Plumbagin, a medicinal plant–derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer
MH Aziz, NE Dreckschmidt, AK Verma - Cancer research, 2008 - AACR
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men.
Hormone-refractory invasive PCa is the end stage and accounts for the majority of PCa …
Hormone-refractory invasive PCa is the end stage and accounts for the majority of PCa …
Risks and benefits of dietary isoflavones for cancer
S Andres, K Abraham, KE Appel… - Critical reviews in …, 2011 - Taylor & Francis
A high intake of fruits and vegetables is associated with a lower risk of cancer. In this context,
considerable attention is paid to Asian populations who consume high amounts of soy and …
considerable attention is paid to Asian populations who consume high amounts of soy and …
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation
DE Clark, TM Errington, JA Smith, HF Frierson Jr… - Cancer research, 2005 - AACR
An increase in the activity of mitogen-activated protein kinase (MAPK) has been correlated
with the progression of prostate cancer to advanced disease in humans. The …
with the progression of prostate cancer to advanced disease in humans. The …
Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor
CT Wu, S Altuwaijri, WA Ricke… - Proceedings of the …, 2007 - National Acad Sciences
Developmental studies of the prostate have established that ductal morphogenesis,
epithelial cytodifferentiation, and proliferation/apoptosis are regulated by androgens acting …
epithelial cytodifferentiation, and proliferation/apoptosis are regulated by androgens acting …